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Antimalarial activity against Plasmodium berghei assessed as reduction in oocyte burden in Anopheles stephensi mosquito midgut fed with blood isolated from compound treated parasite-infected Balb/c mouse at 200 mg/kg administered on day 1 and day 9 relative to control
Assay data:1 Tested
SummaryPubMed Citation
Antimalarial activity against Plasmodium berghei infected in Balb/c mouse assessed as parasite killing at 200 mg/kg administered on day 1 and day 9 relative to control
Antimalarial activity against Plasmodium berghei assessed as reduction in Plasmodium berghei oocyte formation in Anopheles stephensi mosquito midgut fed with blood isolated from compound treated parasite-infected Balb/c mouse at 200 mg/kg administered on day 1 and day 9
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiplasmodial activity against Plasmodium berghei isolated from parasite-infected mouse blood assessed as reduction in number of healthy parasites in compound treated ookinete medium co-cultured with mouse blood at 0.05 to 0.45 uM by giemsa staining based analysis
Drug recovery in C57BL/6 mouse plasma at 0.1 mg/ml
Toxicity in C57BL/6 mouse assessed as effect on kidney structure at 400 mg/kg, ip measured upto 24 hrs by H&E staining based histopathological analysis
Toxicity in C57BL/6 mouse assessed as effect on liver structure at 400 mg/kg, ip measured upto 24 hrs by H&E staining based histopathological analysis
Toxicity in C57BL/6 mouse assessed as effect on globulin level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 4.19 gm/dl)
Toxicity in C57BL/6 mouse assessed as effect on albumin level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 2.10 gm/dl)
Toxicity in C57BL/6 mouse assessed as effect on total protein level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 6.29 gm/dl)
Toxicity in C57BL/6 mouse assessed as effect on serum LDH level at 400 mg/kg, ip measured upto 24 hrs
Toxicity in C57BL/6 mouse assessed as effect on serum calcium level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 8.89 mg/dl)
Toxicity in C57BL/6 mouse assessed as effect on serum uric acid level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 2.58 mg/dl)
Toxicity in C57BL/6 mouse assessed as effect on serum creatinine level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 0.47 mg/dl)
Toxicity in C57BL/6 mouse assessed as effect on urea level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 44.50 mg/dl)
Toxicity in C57BL/6 mouse assessed as effect on alkaline phosphatase level in serum at 400 mg/kg, ip measured upto 24 hrs (Rvb = 108.3 U/L)
Toxicity in C57BL/6 mouse assessed as effect on SGPT level in serum at 400 mg/kg, ip measured upto 24 hrs (Rvb = 37.59 U/L)
Toxicity in C57BL/6 mouse assessed as effect on SGOT level in serum at 400 mg/kg, ip measured upto 24 hrs (Rvb = 147.2 U/L)
Toxicity in C57BL/6 mouse assessed as effect on indirect bilirubin level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 0.22 mg/dl)
Toxicity in C57BL/6 mouse assessed as effect on direct bilirubin level at 400 mg/kg, ip measured upto 24 hrs (Rvb = 0.17 mg/dl)
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