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HTS to identify compounds that affect the blood-brain barrier permeability in vitro
Assay data:419 Active, 1260 Tested
SummaryCompounds, Active
Antiviral activity against HSV-1 K26GFP infected in J cells expressing nectin1 plus alphavbeta8 integrin at 700 uM incubated for 48 hrs followed by viral infection measured after 16 hrs by fluorescent microscopy
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against HSV-1 K26GFP infected in J cells expressing nectin1 plus alphavbeta6 integrin at 700 uM incubated for 48 hrs followed by viral infection measured after 16 hrs by fluorescent microscopy
Assay data:2 Active, 3 Tested
Antiviral activity against HSV-1 K26GFP infected in J cells expressing nectin1 plus alphavbeta6/alphavbeta8 integrin at 700 uM incubated for 48 hrs followed by viral infection measured after 16 hrs by fluorescent microscopy
Assay data:1 Active, 3 Tested
Antiviral activity against HSV-1 R8102 infected in HEK293T cells assessed as inhibition of viral replication upto 1000 uM using ONPG as substrate incubated for 1 hrs followed by viral infection measured after 90 mins by microplate reader analysis relative to control
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of human recombinant integrin alpha5beta1 incubated for 1 hr by ELISA assay
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant integrin alphavbeta3 incubated for 1 hr by ELISA assay
Assay data:1 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant integrin alphavbeta8 incubated for 1 hr by ELISA assay
Inhibition of human recombinant integrin alphavbeta6 incubated for 1 hr by ELISA assay
Assay data:2 Active, 8 Tested
Selectivity ratio of IC50 for alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cells to IC50 for alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human HEK293 cells
Assay data:4 Tested
Inhibition of alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human HEK293 cells
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human SK-OV-3 cells expressing alphavbeta5 integrin receptor
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5603 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
Selectivity index, ratio of IC50 for binding affinity to human integrin alpha5beta1 to IC50 for binding affinity to human integrin alphaVbeta3
Assay data:15 Tested
Binding affinity to human integrin alpha5beta1 incubated for 1 hr by ELISA based solid phase integrin binding assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 16 Tested
Binding affinity to human integrin alphaVbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assay
Assay data:16 Active, 12 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
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