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Inhibitory Assay from US Patent US20240116873: "QUINOLINE MERCAPTOACETATE SULFONAMIDE DERIVATIVE, INTERMEDIATE, PHARMACEUTICAL DERIVATIVE OR FORMULATION, AND PREPARATION METHOD AND USE THEREFOR"
Assay data:8 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary
Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter screen
Assay data:213 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen
Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen
Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested
The drug is tested on Akkermansia muciniphila strain: ATCC BAA-835 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:221 Tested
SummaryPubMed Citation
The drug is tested on Salmonella typhimurium strain: LT2 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:200 Tested
The drug is tested on Providencia stuartii strain: ATCC25827 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:227 Tested
The drug is tested on Providencia rettgeri strain: DSM1131 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:214 Tested
The drug is tested on Providencia alcalifaciens strain: DSM30120 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:203 Tested
The drug is tested on Proteus penneri strain: ATCC35198 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:248 Tested
The drug is tested on Escherichia coli strain: BW25113 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:205 Tested
The drug is tested on Enterobacter cancerogenus strain: ATCC35316 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
The drug is tested on Edwardsiella tarda strain: ATCC23685 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
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