Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
NOS Enzyme Inhibition Assay from Article 10.1038/nchembio.115: "Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase."
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736.
Assay data:1102 Tested
Summary
ASTRAZENECA: Most basic pKa value (pKa B1) determined by absorption and potentiometric titration using standard methodology from Sirius Analytical. Experimental range Bases: >= 2.
Assay data:261 Tested
Binding affinity to mouse iNOSox delta65 (residues 66-498)
Assay data:11 Active, 11 Tested
SummaryCompounds, ActivePubMed Citation
Selectivity ratio of IC50 for human iNOS over IC50 for human nNOS
Assay data:12 Tested
SummaryPubMed Citation
Selectivity ratio of IC50 for human iNOS over IC50 for human eNOS
Inhibition of human nNOS
Assay data:11 Active, 8 Activity ≤ 1 µM, 15 Tested
Inhibition of human eNOS
Assay data:7 Active, 4 Activity ≤ 1 µM, 15 Tested
Inhibition of human iNOS
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on