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Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent inhibition of light emission compared to control. (Single Point Inhibition, %)
Assay data:5855 Active, 687 Activity ≤ 1 µM, 9989 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Assay data:6235 Active, 735 Activity ≤ 1 µM, 9989 Tested
Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay
Assay data:10 Active, 359 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibitors of CDC25B-CDK2/CyclinA interaction
Assay data:680 Active, 93851 Tested
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
Assay data:13179 Tested
SummaryRelated BioAssays by Target
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro
Biochemical screen of P. falciparum MAPK2
Assay data:13451 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical screen of P. falciparum CDPK4
Assay data:55 Active, 55 Activity ≤ 1 µM, 13451 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical screen of P. falciparum PK7
Assay data:2 Active, 2 Activity ≤ 1 µM, 13451 Tested
Biochemical screen of P. falciparum PK6
Assay data:65 Active, 65 Activity ≤ 1 µM, 13451 Tested
Biochemical screen of P. falciparum CDPK1
Assay data:181 Active, 181 Activity ≤ 1 µM, 13451 Tested
Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay
Assay data:72 Active, 16000 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Novartis GNF Liver Stage Dataset: Malariabox Annotation
Assay data:275 Active, 230 Activity ≤ 1 µM, 5697 Tested
NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.
Assay data:655 Active, 4417 Tested
SummaryCompounds, ActivePubMed Citation
NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested.
Assay data:5614 Tested
SummaryPubMed Citation
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
Assay data:399 Active, 59 Activity ≤ 1 µM, 5614 Tested
NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay
Assay data:4616 Active, 9 Activity ≤ 1 nM, 3714 Activity ≤ 1 µM, 5614 Tested
NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay
Assay data:4209 Active, 3 Activity ≤ 1 nM, 3165 Activity ≤ 1 µM, 5614 Tested
Cell-based luminescence-based Maybridge primary high throughput screening assay to identify agonists of NOTCH
Assay data:61 Active, 15360 Tested
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