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Dual reporter qHTS for antagonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA and TCM libraries: Fluorescence Readout
Assay data:28 Active, 4 Activity ≤ 1 µM, 964 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dual reporter qHTS for antagonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA and TCM libraries: Luminescence Readout
Assay data:11 Active, 8 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dual reporter qHTS for agonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA and TCM libraries: Luminescence readout
Assay data:82 Active, 964 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dual reporter qHTS for agonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA and TCM libraries: Fluorescence readout
Assay data:1 Active, 3 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS Counterscreen for compound interference against the NCATS DSHEA and TCM libraries
Assay data:1 Active, 1 Activity ≤ 1 µM, 964 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
KB-8-5-11 P-gp reporter qHTS against the NCATS DSHEA and TCM libraries
Assay data:27 Active, 1 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
qHTS for inhibitors of CYPIA2 against the NCATS DSHEA and TCM libraries
Assay data:275 Active, 13 Activity ≤ 1 µM, 964 Tested
KB-3-1 P-gp reporter qHTS against the NCATS DSHEA and TCM libraries
Assay data:48 Active, 6 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP2C19 against the NCATS DSHEA and TCM libraries
Assay data:350 Active, 13 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP2C9 against the NCATS DSHEA and TCM libraries
Assay data:352 Active, 10 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP2D6 against the NCATS DSHEA and TCM libraries
Assay data:85 Active, 1 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP3A4 against the NCATS DSHEA and TCM libraries
Assay data:330 Active, 10 Activity ≤ 1 µM, 964 Tested
Hepatoprotective activity in ethanol induced liver injury in transgenic zebrafish T3 (L- FABP:EGFP) model assessed as change in liver size at 50 uM incubated for 72 hrs by fluorescence microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Hepatoprotective activity in isoniazid induced liver injury in transgenic zebrafish T3 (L- FABP:EGFP) model assessed as change in liver size at 50 uM incubated for 72 hrs by fluorescence microscopic analysis
HepG2 viability counterscreen (readout 1: protease activity) against the NCATS DSHEA and TCM libraries
Assay data:10 Active, 1 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
HepG2 viability counterscreen (readout 2: ATP content) against the NCATS DSHEA and TCM libraries
Assay data:12 Active, 23 Activity ≤ 1 µM, 964 Tested
Primary qHTS for agonist of constitutive androstane receptor (CAR) against the NCATS DSHEA and TCM libraries
Assay data:78 Active, 1 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Viability counterscreen for agonist of constitutive androstane receptor (CAR) against the NCATS DSHEA and TCM libraries
Assay data:2 Active, 2 Activity ≤ 1 µM, 964 Tested
Viability counterscreen for antagonist of constitutive androstane receptor (CAR) against the NCATS DSHEA and TCM libraries
Assay data:17 Active, 964 Tested
Primary qHTS for antagonist of constitutive androstane receptor (CAR) against the NCATS DSHEA and TCM libraries
Assay data:17 Active, 98 Activity ≤ 1 µM, 964 Tested
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