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Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage at 20 uM preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay relative to control
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage at 100 uM preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay relative to control
Inhibition of SARS-CoV N-terminal 6His-tagged TEV-fused papain-like protease expressed in Escherichia coli BL21(DE3) cells using Z-RLRGG-AMC as substrate by fluorescence method
Assay data:6 Active, 7 Tested
SummaryCompounds, ActivePubMed Citation
Induction of DNA damage in human SU8686 cells assessed as increase in gammaH2AX phosphorylation at ser193 at cytotoxic IC50 in presence of 0.3 uM doxorubicin by fluorometry method
Assay data:39 Tested
SummaryPubMed Citation
Induction of DNA damage in human SU8686 cells assessed as increase in gammaH2AX phosphorylation at ser193 at cytotoxic IC50 in presence of 5 uM cisplatin by fluorometry method
Assay data:17 Tested
Small-molecule inhibitors of ST2 (IL1RL1)
Assay data:1825 Active, 77700 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Increase in SIRT1 (unknown origin) deacetylation activity at 10 uM
Assay data:3 Active, 27 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Assay data:27 Tested
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Inhibition of Streptococcus mutans OMZ65 recombinant sortase A delta-40 mutant using Dabcyl-QALPETGEE-Edans as substrate after 1 hr by fluorescence spectrophotometry
Assay data:10 Tested
Cytotoxicity against NHEM cells assessed as cell viability 24 hrs by WST-8 assay
Assay data:45 Tested
Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation
Assay data:27 Active, 3 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of DNA topoisomerase 2 in human HeLa cells by kinetoplast DNA decantation assay
Assay data:3 Tested
Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method
Assay data:2 Active, 3 Tested
Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method
Antifungal activity against Aspergillus fumigatus
Assay data:1 Tested
Antifungal activity against Cryptococcus neoformans
Antibacterial activity against Staphylococcus aureus
Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-nitroflorene-induced mutation at 150 ug/plate after 72 hrs
Assay data:6 Tested
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