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CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
Proposed mechanism(s) of liver damage. [column 'MEC' in source]
Assay data:1214 Tested
SummaryPubMed Citation
Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
Presence of at least one case with successful reintroduction. [column 'REINT' in source]
Animal toxicity known. [column 'TOXIC' in source]
Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is number of references indexed. [column 'AIGUE' in source]
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