BioAssays for PubChem Compound (Select 57379345) - PubChem BioAssay - NCBI

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Select item 19635961.

Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: cytochrome P450 3A7 [Homo sapiens]

Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested

AID:: 1963596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19620162.

Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.

Source:: ChEMBL

Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested

AID:: 1962016

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19620133.

Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGFP-labeled Green monkey Vero cells by fluorescence imaging.

Source:: ChEMBL

Assay data:19 Active, 7 Activity ≤ 1 µM, 134 Tested

AID:: 1962013

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19614184.

Inhibition of ACK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Activated CDC42 kinase 1

Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested

AID:: 1961418

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19557065.

Selectivity ratio, ratio of IC50 for human NCI-H2228 cells expressing ALK to IC50 for human HK-2 cells by MTT assay

Source:: ChEMBL

Assay data:2 Tested

AID:: 1955706

Summary PubMed Citation

Select item 19557046.

Selectivity ratio, ratio of IC50 for human NCI-H2228 cells expressing ALK to IC50 for human EA.hy 926 cells by MTT assay

Source:: ChEMBL

Assay data:2 Tested

AID:: 1955704

Summary PubMed Citation

Select item 19557027.

Cytotoxicity against human HK-2 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by MTT assay

Source:: ChEMBL

Assay data:3 Active, 3 Tested

AID:: 1955702

Summary Compounds, Active PubMed Citation

Select item 19557018.

Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by MTT assay

Source:: ChEMBL

Assay data:3 Active, 3 Tested

AID:: 1955701

Summary Compounds, Active PubMed Citation

Select item 19220969.

Inhibition of c-MET (unknown origin)

Source:: ChEMBL

Protein Target:: Hepatocyte growth factor receptor

Assay data:1 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1922096

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192209510.

Inhibition of EGFR (unknown origin)

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:4 Activity ≤ 1 µM, 4 Tested

AID:: 1922095

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192209411.

Inhibition of ALK L1196M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1922094

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192209312.

Inhibition of wild type ALK (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1922093

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192209213.

Antiproliferative activity against human A549 cells by MTT assay

Source:: ChEMBL

Assay data:6 Active, 26 Tested

AID:: 1922092

Summary Compounds, Active PubMed Citation

Select item 192209114.

Antiproliferative activity against human NCI-H2228 cells by MTT assay

Source:: ChEMBL

Assay data:25 Active, 12 Activity ≤ 1 µM, 26 Tested

AID:: 1922091

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 192209015.

Antiproliferative activity against human KARPAS-299 cells by MTT assay

Source:: ChEMBL

Assay data:26 Active, 22 Activity ≤ 1 µM, 26 Tested

AID:: 1922090

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 191896916.

Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:281 Active, 189401 Tested

AID:: 1918969

Summary Compounds, Active

Select item 191568717.

Cytotoxicity against mouse BaF3 cells expressing human EGFR C797S/T790M/del19 mutant assessed as inhibition of in cell viability measured after 72 hrs by CellTiter-Glo assay

Source:: ChEMBL

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1915687

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 191568618.

Cytotoxicity against mouse BaF3 cells expressing human EGFR C797S/del19 mutant assessed as inhibition of in cell viability measured after 72 hrs by CellTiter-Glo assay

Source:: ChEMBL

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1915686

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189220119.

Inhibition of wild type N-terminal GST tagged ALK G1202R mutant cytoplasmic domain (1058 to 1620 end residues) (unknown origin) expressed in Sf21 cells incubated for 1 hr in presence of ATP

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:4 Active, 5 Activity ≤ 1 µM, 13 Tested

AID:: 1892201

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189220020.

Inhibition of wild type N-terminal GST tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 end residues) (unknown origin) expressed in Sf21 cells incubated for 1 hr in presence of ATP

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 13 Tested

AID:: 1892200

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (20)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (900)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (76)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (612)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (59)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (675)
BioAssays extracted from the literature
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BioAssays deposited by the NIH Molecular Libraries Program
Other (472)
BioAssays deposited by other experimentalists

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