BioAssays for PubChem Compound (Select 5793) - PubChem BioAssay - NCBI

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Select item 19124661.

Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells (PubChem AID: 1794827)

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 3

Assay data:1 Active, 4 Tested

AID:: 1912466

Summary Compounds, Active Related BioAssays by Target

Select item 19124652.

Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells (PubChem AID: 1794828)

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 4

Assay data:3 Active, 4 Tested

AID:: 1912465

Summary Compounds, Active Related BioAssays by Target

Select item 19124643.

Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells (PubChem AID: 1794829)

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 2

Assay data:4 Tested

AID:: 1912464

Summary Related BioAssays by Target

Select item 19124634.

Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells (PubChem AID: 1794830)

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1912463

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18728745.

Inhibition of yeast alpha-glucosidase

Source:: ChEMBL

Assay data:1 Active, 2 Tested

AID:: 1872874

Summary Compounds, Active PubMed Citation

Select item 17948306.

Flow cytometry transport assay for SLC2A1 using HEK293 JumpIN TRex SLC2A1 WT-OE cells

Source:: RESOLUTE - Research Empowerment on Solute Carriers

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1794830

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 17948297.

Flow cytometry transport assay for SLC2A2 using HEK293 JumpIN TRex SLC2A2 WT-OE cells

Source:: RESOLUTE - Research Empowerment on Solute Carriers

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 2

Assay data:1 Active, 4 Tested

AID:: 1794829

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 17948288.

Flow cytometry transport assay for SLC2A4 using HEK293 JumpIN TRex SLC2A4 WT-OE cells

Source:: RESOLUTE - Research Empowerment on Solute Carriers

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 4

Assay data:4 Active, 4 Tested

AID:: 1794828

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 17948279.

Flow cytometry transport assay for SLC2A3 using HEK293 JumpIN TRex SLC2A3 WT-OE cells

Source:: RESOLUTE - Research Empowerment on Solute Carriers

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 3

Assay data:2 Active, 4 Tested

AID:: 1794827

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 167149810.

Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging

Source:: ChEMBL

Assay data:2 Activity ≤ 1 µM, 4309 Tested

AID:: 1671498

Summary Compounds, activity ≤ 1 µM

Select item 163702111.

Induction of insulin secretion in human pancreatic islets at 2 to 12 mM

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1637021

Summary Compounds, Active PubMed Citation

Select item 161961312.

Binding affinity to V5-His tagged FIBCD1 ecto-domain (54 to 461 residues) (unknown origin) expressed in HEK293 cells assessed as reduction in binding between FIBCD1 and acetylated BSA by ELISA

Source:: ChEMBL

Protein Target:: Fibrinogen C domain-containing protein 1

Assay data:16 Tested

AID:: 1619613

Summary Related BioAssays by Target

Select item 161961213.

Binding affinity to V5-His tagged FIBCD1 ecto-domain (54 to 461 residues) (unknown origin) assessed as reduction in binding between FIBCD1 and acetylated BSA at 50 mM by ELISA relative to control

Source:: ChEMBL

Protein Target:: Fibrinogen C domain-containing protein 1

Assay data:9 Tested

AID:: 1619612

Summary Related BioAssays by Target

Select item 149269714.

Inhibition of GLUT1-mediated 2NBDG uptake in human Caco2 cells at 1 to 10 mM after 10 mins by Hoechst 33342 staining based fluorescence assay

Source:: ChEMBL

Protein Target:: Solute carrier family 2, facilitated glucose transporter member 1

Assay data:1 Active, 1 Tested

AID:: 1492697

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 147416715.

Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status

Source:: ChEMBL

Assay data:929 Tested

AID:: 1474167

Summary PubMed Citation

Select item 147416616.

Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index

Source:: ChEMBL

Assay data:929 Tested

AID:: 1474166

Summary PubMed Citation

Select item 141912617.

Substrate activity at hexokinase (unknown origin) assessed as compound phosphorylation after 1 days in presence of ATP by 31-P NMR spectroscopic analysis

Source:: ChEMBL

Assay data:2 Active, 4 Tested

AID:: 1419126

Summary Compounds, Active PubMed Citation

Select item 140960518.

Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits)

Source:: ChEMBL

Assay data:1629 Tested

AID:: 1409605

Select item 137394419.

Inhibition of Escherichia coli Heptosyltransferase I assessed as reduction in ADP release using ODLA and ADP-heptose substrates in presence of phospho(enol)pyruvate and NADH by pyruvate kinase and LDH based ADP/NADH coupling assay

Source:: ChEMBL

Protein Target:: Lipopolysaccharide heptosyltransferase 1

Assay data:8 Tested

AID:: 1373944

Summary PubMed Citation Related BioAssays by Target

Select item 137394320.

Inhibition of Escherichia coli Heptosyltransferase I assessed as reduction in ADP release at 1 mM using ODLA and ADP-heptose substrates in presence of phospho(enol)pyruvate and NADH by pyruvate kinase and LDH based ADP/NADH coupling assay

Source:: ChEMBL

Protein Target:: Lipopolysaccharide heptosyltransferase 1

Assay data:21 Tested

AID:: 1373943

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (25)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (46)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (13)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (28)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (48)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (26)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (70)
BioAssays extracted from the literature
NIH MLP (26)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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