BioAssays for PubChem Compound (Select 6083) - PubChem BioAssay - NCBI

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Select item 19635851.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested

AID:: 1963585

Select item 19635842.

p53 small molecule agonists, cell-based qHTS assay: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested

AID:: 1963584

Select item 19635833.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested

AID:: 1963583

Select item 19635824.

p53 small molecule agonists, cell-based qHTS assay

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested

AID:: 1963582

Select item 19635815.

p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter screen

Source:: Tox21

Assay data:213 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 9667 Tested

AID:: 1963581

Select item 19635806.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested

AID:: 1963580

Select item 19635797.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested

AID:: 1963579

Select item 19635788.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested

AID:: 1963578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19635779.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested

AID:: 1963577

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 196187810.

Binding affinity towards human HRH3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Histamine H3 receptor

Assay data:41 Active, 7 Activity ≤ 1 µM, 993 Tested

AID:: 1961878

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185811.

Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested

AID:: 1961858

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185612.

Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(3) dopamine receptor

Assay data:176 Active, 1 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 1215 Tested

AID:: 1961856

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185513.

Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Assay data:49 Active, 5 Activity ≤ 1 µM, 1243 Tested

AID:: 1961855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185214.

Compound was evaluated for inhibition of human MAOA in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Amine oxidase [flavin-containing] A

Assay data:28 Active, 4 Activity ≤ 1 µM, 1218 Tested

AID:: 1961852

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184915.

Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent serotonin transporter

Assay data:148 Active, 75 Activity ≤ 1 µM, 1194 Tested

AID:: 1961849

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184816.

Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent noradrenaline transporter

Assay data:123 Active, 40 Activity ≤ 1 µM, 1197 Tested

AID:: 1961848

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184717.

Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent dopamine transporter

Assay data:119 Active, 21 Activity ≤ 1 µM, 1213 Tested

AID:: 1961847

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184618.

Binding affinity towards human TBXA2R in an in vitro assay with cellular components measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:14 Active, 2 Activity ≤ 1 µM, 1022 Tested

AID:: 1961846

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182719.

Compound was evaluated for inhibition of human PTGS2 in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 2

Assay data:79 Active, 12 Activity ≤ 1 µM, 1183 Tested

AID:: 1961827

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182520.

Compound was evaluated for inhibition of rat Ptgs1 in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:74 Active, 33 Activity ≤ 1 µM, 1201 Tested

AID:: 1961825

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (224)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (536)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (142)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (403)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (65)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (463)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (18)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (238)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (250)
BioAssays extracted from the literature
NIH MLP (107)
BioAssays deposited by the NIH Molecular Libraries Program
Other (265)
BioAssays deposited by other experimentalists

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