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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Toxicity in iv dosed nude mouse xenografted with human SW480 cells assessed as effect on body weight administered at 3 days intervals for 21 days
Assay data:1 Tested
Induction of apoptosis in human SW480 cells assessed as necrotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 3.05 %)
Assay data:2 Tested
Induction of apoptosis in human SW480 cells assessed as late apoptotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 5.12 %)
Induction of apoptosis in human SW480 cells assessed as early apoptotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 2.53 %)
Induction of apoptosis in human SW480 cells assessed as viable cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 89.3 %)
Induction of apoptosis in human HCT-116 cells assessed as necrotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 0.73 %)
Induction of apoptosis in human HCT-116 cells assessed as late apoptotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 3.51 %)
Induction of apoptosis in human HCT-116 cells assessed as early apoptotic cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 1.46 %)
Induction of apoptosis in human HCT-116 cells assessed as viable cells at 25 uM by Annexin V-FITC staining based flow cytometry (Rvb = 94.3%)
Antimigratory activity against human SW480 cells assessed as inhibition of cell migration by wound healing assay relative to control
Antimigratory activity against human HCT-116 cells assessed as inhibition of cell migration by wound healing assay relative to control
Selectivity index, ratio of IC50 for cytotoxicity against HEK293T cells to IC50 for anticancer activity against human HCT-116 cells
Selectivity index, ratio of IC50 for cytotoxicity against HEK293T cells to IC50 for anticancer activity against human SW480 cells
Selectivity index, ratio of IC50 for cytotoxicity against human L02 cells to IC50 for anticancer activity against human SW480 cells
Selectivity index, ratio of IC50 for cytotoxicity against human L02 cells to IC50 for anticancer activity against human HCT-116 cells
Cytotoxicity against human L02 cells assessed as inhibition of cell growth by MTT assay
Assay data:1 Active, 2 Tested
Cytotoxicity against HEK293T cells assessed as inhibition of cell growth by MTT assay
Solubility of the compound in Tween 80 solution
Assay data:3 Tested
Solubility of the compound in 0.9% NaCl solution
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