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Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate at 100 uM incubated for 2 mins by BCA assay relative to control
Assay data:1 Active, 25 Tested
SummaryRelated BioAssays by Target
Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate at 10 uM incubated for 2 mins by BCA assay relative to control
Assay data:1 Active, 30 Tested
Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate incubated for 2 mins by BCA assay
Assay data:7 Active, 2 Activity ≤ 1 µM, 24 Tested
Anti-hepatic fibrosis activity in human LX2 cells assessed as inhibition of COL1A1 promoter activity at 25 micromol/L by luciferase reporter assay relative to control
Assay data:56 Tested
Summary
Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation incubated for 24 hrs by ThioflavinT-dye based fluorescence analysis
Assay data:9 Active, 4 Activity ≤ 1 µM, 9 Tested
Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation at 100 uM incubated for 24 hrs by ThioflavinT-dye based fluorescence analysis
Assay data:9 Tested
Inhibition of human alpha-syn expressed in Escherichia coli BL21 (DE3) cells aggregation at 400 uM incubated at compound:protein ratio of 5:1 for 36 hrs by ThT dye based fluorescence assay relative to control
Assay data:7 Tested
Inhibition of human alpha-syn expressed in Escherichia coli BL21 (DE3) cells aggregation at 80 uM incubated at compound:protein ratio of 1:1 for 36 hrs by ThT dye based fluorescence assay relative to control
Assay data:6 Tested
Binding affinity to human alpha-syn expressed in Escherichia coli BL21 (DE3) cells assessed as protein-compound complex formation at 100 uM incubated for 3 hrs by ESI-MS spectrum analysis
Assay data:15 Active, 16 Tested
Inhibition of DYRK1A (unknown origin)
Assay data:21 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 25 Tested
Inhibition of amyloid beta (unknown origin) aggregation
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of human BACE-1
Assay data:5 Active, 5 Tested
Activation of cGAMP-STING signaling pathway in human THP-1 cells assessed as increase in ISRE activation at 3.125 uM in presence of 10 ug/ml cGAMP by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Assay data:17 Active, 4 Activity ≤ 1 µM, 56 Tested
Selectivity ratio of IC50 for recombinant human DYRK1B expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Escherichia coli
Assay data:35 Tested
Selectivity ratio of IC50 for recombinant human CLK1 expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Escherichia coli
Assay data:34 Tested
Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:34 Active, 31 Activity ≤ 1 µM, 35 Tested
Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:35 Active, 32 Activity ≤ 1 µM, 35 Tested
Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:32 Active, 29 Activity ≤ 1 µM, 35 Tested
Selectivity ratio of IC50 for recombinant human GSK-3beta expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Sf9 insect cells
Assay data:48 Tested
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