BioAssays, Active for PubChem Compound (Select 135309104) - PubChem BioAssay - NCBI

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Items: 9

Select item 19141591.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000720a GABRA1

Source:: ChEMBL

Protein Target:: Gamma-aminobutyric acid receptor subunit alpha-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914159

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19141582.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000720a ADRA2A

Source:: ChEMBL

Protein Target:: Alpha-2A adrenergic receptor

Assay data:1 Active, 1 Tested

AID:: 1914158

Summary Compounds, Active Related BioAssays by Target

Select item 19141563.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000720a HTR2A

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:1 Active, 1 Tested

AID:: 1914156

Summary Compounds, Active Related BioAssays by Target

Select item 19131904.

Affinity Biochemical interaction (TR-FRET binding assay (Invitrogen)) EUB0000720a RIPK1

Source:: ChEMBL

Protein Target:: Receptor-interacting serine/threonine-protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913190

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127635.

Affinity Phenotypic Cellular interaction (CytoTox 96 nonradioactive cytotoxicity assay (necroptosis in HT29 cells; Promega)) EUB0000720a RIPK1

Source:: ChEMBL

Protein Target:: Receptor-interacting serine/threonine-protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912763

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17944446.

GPCRScan assay: inhibition of GABA/PBR

Source:: ChEMBL

Assay data:16 Active, 19 Activity ≤ 1 µM, 181 Tested

AID:: 1794444

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 17932877.

TR-FRET (mouse RIPK1)

Source:: ChEMBL

Protein Target:: Receptor-interacting serine/threonine-protein kinase 1

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1793287

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17932868.

HT29 necroptosis assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1793286

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 17932859.

TR-FRET (human RIPK1)

Source:: ChEMBL

Protein Target:: Receptor-interacting serine/threonine-protein kinase 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1793285

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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BioActivity

Active Compounds (9)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (7)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (9)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Other (9)
BioAssays deposited by other experimentalists

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BioAssays, Active for PubChem Compound (Select 135309104) (9)
PubChem BioAssay
Homo sapiens extracellular matrix protein 2 (ECM2), transcript variant 1, mRNA
Homo sapiens extracellular matrix protein 2 (ECM2), transcript variant 1, mRNA
gi|308818202|ref|NM_001393.3|

Nucleotide
Irak3 interleukin-1 receptor-associated kinase 3 [Rattus norvegicus]
Irak3 interleukin-1 receptor-associated kinase 3 [Rattus norvegicus]
Gene ID:314870

Gene
Gene Links for GEO Profiles (Select 119183183) (1)
Gene

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