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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Antiviral activity against influenza A virus
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of aurora B kinase (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
MELK Inhibitor Library Screening assay from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:13 Active, 3 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from Article 10.1021/acschembio.5b00940: "Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands."
Assay data:38 Active, 25 Activity ≤ 1 µM, 47 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS
Assay data:25 Active, 678 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate preincubated for 60 mins followed by substrate addition by microfluidic assay
Assay data:31 Active, 3 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 32 Tested
Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Assay data:237 Active, 1947 Activity ≤ 1 µM, 141380 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as substrate measured after 30 mins in presence of [gamma32P]ATP by liquid scintillation counting method
Assay data:19 Active, 3 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of Xenopus laevis aurora B (60 to 361 residues)/INCENP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation
Assay data:347 Active, 1 Activity ≤ 1 nM, 215 Activity ≤ 1 µM, 650 Tested
qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary
Assay data:378 Active, 203 Activity ≤ 1 µM, 2480 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells
Assay data:264 Active, 736 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells
Assay data:261 Active, 736 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells
Assay data:259 Active, 736 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells
Assay data:235 Active, 736 Tested
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