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Enzyme Assay from Article 10.1002/cbic.200800782: "Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT."
Assay data:9 Active, 6 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Zymomonas mobilis tRNA-guanine transglycosylase expressed in Escherichia coli cells BL21-CodonPlus (DE3)-RIPL in presence of and tRNATyr [-3H]-guanine incubated for 60 mins by liquid scintillation counting based radioactive assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Zymomonas mobilis TGT D156N mutant expressed in Escherichia coli Rosetta 2(DE3) by isothermal titration calorimetric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Zymomonas mobilis TGT D102N mutant overexpressed in Escherichia coli BL21(DE3) by isothermal titration calorimetric analysis
Binding affinity to wild-type Zymomonas mobilis TGT overexpressed in Escherichia coli BL21(DE3) by isothermal titration calorimetric analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
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