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Cmax in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to recombinant human iNOS assessed as dissociation constant by surface plasmon resonance assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human iNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Neuroprotective activity against MPTP/probenedcic-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in DOPA decarboxylase expression in SNpc at 1 to 2 mg/kg, ig pretreated with MPTP/probenecid for 32 days followed by compound addition for next 20 days and measured after 20 days by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as decrease in caspase-3 level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as decrease in caspase-9 level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as increase in Bcl2/Bax ratio level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in striatum at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunoblotting method
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in striatum at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunohistochemistry method
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as decrease in NO level in striatum at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Griess reagent based assay
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in DA level in striatum at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by ELISA
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in SNpc at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunoblotting method
Neuroprotective activity against MPTP/probenedcic-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in TH expression in SNpc at 1 to 2 mg/kg, ig pretreated with MPTP/probenecid for 32 days followed by compound addition for next 20 days and measured after 20 days by Western blot analysis
Neuroprotective activity in MPTP/probenecid -induced C57BL/6 mouse model of Parkinson's disease at 1 to 2 mg/kg, po pretreated with MPTP/probenecid for 32 days followed by compound addition for next 20 days and measured after 52 to 54 days post MPTP challenge by open-field test
Assay data:1 Active, 2 Tested
Neuroprotective activity in MPTP/probenecid -induced C57BL/6 mouse model of Parkinson's disease at 1 to 2 mg/kg, po pretreated with MPTP/probenecid for 32 days followed by compound addition for next 20 days and measured after 52 to 54 days post MPTP challenge by rotarod test
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in SNpc at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunohistochemistry method
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as decrease in NO level in SNpc at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Griess reagent based assay
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in DA level in SNpc at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by ELISA
Neuroprotective activity in MPTP-induced C57BL/6 mouse model of Parkinson's disease at 1 to 2 mg/kg, po pre-administered daily for 10 days followed by MPTP challenge and measured at 4 to 72 hrs post MPTP challenge by rotarod test
Neuroprotective activity in MPTP-induced C57BL/6 mouse model of Parkinson's disease at 1 to 2 mg/kg, po pre-administered daily for 10 days followed by MPTP challenge and measured at 4 to 72 hrs post MPTP challenge by open-field test
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