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Anticonvulsant activity in mouse by measuring free brain concentration
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Anticonvulsant activity in Kunming mouse assessed as reduction in MES-induced seizure at 30 mg/kg, ip measured after 30 mins
Assay data:4 Active, 8 Tested
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation assessed as protein-compound complex formation at 5 to 50 uM by surface plasmon resonance assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of full length mouse Frizzled-8 transfected in Frizzled-1/2/7 knockout HEK293T cells using lentiviral expression system cotransfected with Renilla luciferase assessed as reduction in Wnt3a signaling by measuring luciferase activity at 8 to 64 uM measured after 24 hrs by Dual-Glo luciferase reporter assay
MELAS cybrid survival enhancement under low glucose conditions
Assay data:264 Active, 4937 Tested
Human pregnane X receptor (PXR) small molecule agonists: Summary
Assay data:2076 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibition of human Nav1.2 expressed in CHOK1 cells assessed as reduction in peak inward current at 30th pulse using holding potential of -50 mV by patch clamp assay
Assay data:3 Active, 3 Tested
Acetylcholinesterase (AChE) small molecule antagonists: colormetric cell-based qHTS assay
Assay data:445 Active, 57 Activity ≤ 1 µM, 9667 Tested
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay
Assay data:2218 Active, 1 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Anticonvulsant activity in Swiss albino mouse assessed as protection against subcutaneously injected metrazol induced seizures at 300 mg/kg, ip after 4 hrs
Assay data:6 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against subcutaneously injected metrazol induced seizures at 100 mg/kg, ip after 4 hrs
Assay data:2 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against subcutaneously injected metrazol induced seizures at 300 mg/kg, ip after 0.5 hrs
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 4 hrs
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 4 hrs
Assay data:3 Active, 16 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs
Assay data:8 Active, 15 Tested
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.5 hrs
Anticonvulsant activity in Swiss albino mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.5 hrs
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