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Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting
Assay data:148 Active, 75 Activity ≤ 1 µM, 1194 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human OPRK1 in an in vitro assay with cellular components measured by membrane filtration, scintillation proximity assay
Assay data:179 Active, 30 Activity ≤ 1 µM, 1124 Tested
Binding affinity towards human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:101 Active, 19 Activity ≤ 1 µM, 846 Tested
Compound was evaluated for inhibition of human KCNH2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
Assay data:353 Active, 116 Activity ≤ 1 µM, 1804 Tested
Binding affinity towards rat Ar in an in vitro cell free assay measured by fluorescence polarization method
Assay data:45 Active, 19 Activity ≤ 1 µM, 667 Tested
Antagonist activity at TRPM8 (unknown origin)
Assay data:16 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
NCATS Human Liver Microsomal (HLM) Stability Profiling
Assay data:542 Active, 900 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS12PE_JCRB cell viability assay
Assay data:722 Active, 26 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: INA6_PLB cell viability assay
Assay data:965 Active, 40 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMM1_JCRB cell viability assay
Assay data:606 Active, 18 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: ARD_JJKsccE7 cell viability assay
Assay data:643 Active, 44 Activity ≤ 1 nM, 452 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: AMO1_DSMZ cell viability assay
Assay data:746 Active, 20 Activity ≤ 1 nM, 455 Activity ≤ 1 µM, 1912 Tested
Binding Assay from Article 10.1074/jbc.M109.017632: "Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines."
Assay data:6 Active, 3 Activity ≤ 1 µM, 7 Tested
Binding Assay from Article 10.1074/jbc.M110.164293: "Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen."
Assay data:5 Active, 5 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of cigarette smoke extract (CSE) and LPS-stimulated mouse B cell migration at 1 uM relative to control
Assay data:18 Active, 18 Tested
SummaryCompounds, Active
Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiology
Assay data:14 Active, 8 Activity ≤ 1 µM, 16 Tested
Inhibition of human TRPM2 expressed in HEK293T cells assessed as suppression of H2O2-induced calcium flux at 30 uM measured after 30 mins by Fluo-3/AM assay
Assay data:15 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP3A4 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis
Assay data:9 Active, 2 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antileishmanial activity against Leishmania infantum chagasi MHOM/BR/1972/LD promastigote forms infected in golden hamster after 48 hrs by Alamar Blue assay
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
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