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Competition Binding Assays from Article 10.1021/acschembio.5b01063: "Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors."
Assay data:26 Active, 2 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Non-Small Cell Lung cell line, single concentration
Assay data:2145 Active, 74774 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration
Assay data:3589 Active, 71200 Tested
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Non-Small Cell Lung cell line, single concentration
Assay data:4429 Active, 72551 Tested
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration
Assay data:2950 Active, 69617 Tested
NCI human tumor cell line growth inhibition assay. Data for the UO-31 Non-Small Cell Lung cell line, single concentration
Assay data:3630 Active, 76159 Tested
NCI human tumor cell line growth inhibition assay. Data for the SF-539 Non-Small Cell Lung cell line, single concentration
Assay data:4611 Active, 75990 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.
Assay data:50 Active, 1 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 243 Tested
Assay data:25 Active, 5 Activity ≤ 1 µM, 240 Tested
Assay data:51 Active, 26 Activity ≤ 1 µM, 242 Tested
Assay data:36 Active, 10 Activity ≤ 1 µM, 243 Tested
Assay data:18 Active, 11 Activity ≤ 1 µM, 243 Tested
Assay data:27 Active, 12 Activity ≤ 1 µM, 243 Tested
Assay data:19 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 238 Tested
Assay data:22 Active, 6 Activity ≤ 1 µM, 243 Tested
Assay data:26 Active, 16 Activity ≤ 1 µM, 243 Tested
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