BioAssays, Active for PubChem Compound (Select 44259) - PubChem BioAssay - NCBI

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Select item 19636541.

IRAK4 Kinase Activity Assay from US Patent US11958831: "Pyrazole compounds, pharmaceutical compositions thereof and use thereof"

Source:: BindingDB

Protein Targets:: Interleukin-1 receptor-associated kinase 4; ...
Total:: 1

Assay data:44 Active, 22 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested

AID:: 1963654

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19620162.

Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.

Source:: ChEMBL

Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested

AID:: 1962016

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19606663.

Inhibition of N-terminal GST-tagged full length human BTK (2 to 659 residues) expressed in Sf21 insect cells using 5-FAM-EAIYAAPFAKKK as substrate incubated for 60 mins

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960666

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606644.

Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 1; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960664

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606635.

Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-A2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960663

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606626.

Inhibition of recombinant full length human C-terminal His6-tagged CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombinant full length human MAT1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: CDK-activating kinase assembly factor MAT1; ...
Total:: 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960662

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606617.

Inhibition of C-terminal His6 tagged full length recombinant human CDK9/full length human Cyclin T1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-T1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960661

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606608.

Inhibition of full length human CDK6/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 6; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960660

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606599.

Inhibition of full length human CDK4/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 4; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960659

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195568210.

Inhibition of ALK (unknown origin) pre-incubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by mobility shifting assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1955682

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195548211.

Inhibition of CDK6/Cyclin D3 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 6; ...
Total:: 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1955482

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195548112.

Inhibition of CDK4/Cyclin D1 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 4; ...
Total:: 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1955481

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195474713.

Inhibition of GSK-3beta (unknown origin)

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:11 Active, 11 Activity ≤ 1 µM, 12 Tested

AID:: 1954747

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195402014.

Inhibition of telomerase activity in human SGC-7901 cells incubated for 24 hrs by TRAP-PCR-ELISA assay

Source:: ChEMBL

Protein Target:: Telomerase reverse transcriptase

Assay data:3 Active, 4 Tested

AID:: 1954020

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 195080915.

Inhibition of DYRK1A (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:21 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 25 Tested

AID:: 1950809

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194863916.

Binding affinity to recombinant MERTK (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Mer

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948639

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194863817.

Binding affinity to recombinant MST3 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 24

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948638

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194863718.

Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948637

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194863619.

Binding affinity to recombinant CDK2 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948636

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194863520.

Binding affinity to recombinant MAPK15 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 15

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948635

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (1,000)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (146)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (915)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (774)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (788)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (209)
BioAssays deposited by other experimentalists

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