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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Cmax in rat at 20 mg/kg, po
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of rat 11beta-HSD2 in adipose tissue microsome
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary
Assay data:1038 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibtion of CYP1A (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Anti-tumor activity against human ishikawa cells assessed as anti-estrogenic potential
Assay data:1 Active, 2 Tested
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 6 hrs by SRB assay
Assay data:10 Active, 4 Activity ≤ 1 µM, 10 Tested
HTS to identify compounds that affect the blood-brain barrier permeability in vitro
Assay data:419 Active, 1260 Tested
SummaryCompounds, Active
Synergistic cytotoxicity against human HSC-2 cells
Dual reporter qHTS for agonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA and TCM libraries: Luminescence readout
Assay data:82 Active, 964 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS for inhibitors of CYPIA2 against the NCATS DSHEA and TCM libraries
Assay data:275 Active, 13 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS for inhibitors of CYP2C19 against the NCATS DSHEA and TCM libraries
Assay data:350 Active, 13 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP2C9 against the NCATS DSHEA and TCM libraries
Assay data:352 Active, 10 Activity ≤ 1 µM, 964 Tested
qHTS for inhibitors of CYP3A4 against the NCATS DSHEA and TCM libraries
Assay data:330 Active, 10 Activity ≤ 1 µM, 964 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Antioxidant activity assessed as Fe2+/ascorbate-induced MDA level in liver mitochondria (unknown origin) preincubated for 30 mins followed by addition of Fe2+/ascorbate measured after 30 mins
Antibacterial activity against Bacillus cereus ATCC 10987 assessed as membrane potential change at 0.5 to 2X MIC incubated for 20 mins by DiSC3(5) staining based assay
Assay data:5 Active, 5 Tested
Bactericidal activity against Staphylococcus aureus LMG 8224 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method
Bactericidal activity against Enterococcus faecalis LMG 16003 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method
Assay data:1 Active, 1 Tested
Bactericidal activity against Enterococcus faecalis V583 at 128 uM measured upto 24 hrs by CLSI based broth microdilution method
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