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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Agonist activity at human GABRA1 in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:2 Active, 293 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in photoincorporation at M236 residues of alpha1 subunit measured after 30 mins in presence of GABA by liquid scintillation counting method
Assay data:1 Active, 5 Tested
Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins by liquid scintillation counting method
Assay data:2 Active, 5 Tested
Anesthetic activity in Xenopus laevis tadpoles assessed as increase in loss of righting reflex incubated for 30 to 60 mins
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Cmax in Beagle dog at 6.9 mg/kg, po by LC-MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Caspase-3/7 induction in HepG2 cells by small molecules, qHTS assay: Summary
Assay data:415 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Human pregnane X receptor (PXR) small molecule agonists: Summary
Assay data:2076 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Cmax in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Displacement of [35S]TBPS from GABAA receptor in Wistar rat cerebral cortex membranes after 3 hrs by scintillation counting method
Assay data:1 Active, 1 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells
Assay data:719 Active, 4426 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells
Assay data:805 Active, 4425 Tested
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay
Assay data:2218 Active, 1 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
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