BioAssays, Active for PubChem Compound (Select 49836093) - PubChem BioAssay - NCBI

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Items: 17

Select item 19220371.

Inhibition of Nav1.6 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922037

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19220362.

Inhibition of Nav1.2 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922036

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19220273.

Inhibition of human Nav1.7

Source:: ChEMBL

Protein Target:: Sodium channel protein type 9 subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922027

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19220264.

Inhibition of human Nav1.5

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922026

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18022495.

In Vitro Assay from US Patent US9260446: "Synthetic methods for spiro-oxindole compounds"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 9 subunit alpha; ...
Total:: 1

Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1802249

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17949046.

Guanidine Influx Assay from US Patent US9695185: "Synthetic methods for spiro-oxindole compounds"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 9 subunit alpha; ...
Total:: 1

Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1794904

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 15253947.

Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 10 subunit alpha

Assay data:2 Active, 7 Tested

AID:: 1525394

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15253938.

Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 8 subunit alpha

Assay data:11 Active, 10 Activity ≤ 1 µM, 13 Tested

AID:: 1525393

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15253929.

Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:9 Active, 7 Activity ≤ 1 µM, 14 Tested

AID:: 1525392

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 152538910.

Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:11 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 12 Tested

AID:: 1525389

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 152538411.

Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 7 subunit alpha

Assay data:14 Active, 5 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 15 Tested

AID:: 1525384

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 142552412.

Cmax in human at 4 to 8% (w/w) administered topically as ointment for 21 consecutive days during phase-1 clinical trial

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1425524

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 142549113.

Binding affinity to inactivated state of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 9 subunit alpha

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1425491

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 142549014.

Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in 14C-guanidinium influx by scintillation counting analysis

Source:: ChEMBL

Protein Target:: Sodium channel protein type 9 subunit alpha

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1425490

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 142551115.

Analgesic activity in human assessed as dental pain relief at 500 mg administered as single dose measured 4 to 12 hrs post dose

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1425511

Summary Compounds, Active

Select item 142549916.

Analgesic activity in rat model of chronic constriction injury-induced neuropathic pain assessed as reversal of pain response at 2% (w/v) administered topically as ointment measured upto 1 hr by electrovonfrey anesthesiometry

Source:: ChEMBL

Assay data:2 Active, 3 Tested

AID:: 1425499

Summary Compounds, Active

Select item 142549317.

Analgesic activity in rat model of CFA-induced chronic inflammatory pain assessed as reduction in nociceptive threshold at 200 mg/kg, po by Von Frey filament assay

Source:: ChEMBL

Assay data:2 Active, 2 Tested

AID:: 1425493

Summary Compounds, Active

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BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (13)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (14)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (11)
BioAssays extracted from the literature
Other (6)
BioAssays deposited by other experimentalists

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BioAssays, Active for PubChem Compound (Select 49836093) (17)
PubChem BioAssay
cytochrome oxidase subunit 1, partial (mitochondrion) [Anagrus sp. BOLD:AAN8044]
cytochrome oxidase subunit 1, partial (mitochondrion) [Anagrus sp. BOLD:AAN8044]
gi|1018226055|gb|AMY42753.1|

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