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Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy
Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human PDE4D in an in vitro cell free assay measured by scintillation proximity assay
Assay data:109 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 1242 Tested
Binding affinity towards human OPRM1 in an in vitro assay with cellular components measured by scintillation counting
Assay data:117 Active, 24 Activity ≤ 1 µM, 927 Tested
Agonist activity at human OPRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:43 Active, 9 Activity ≤ 1 µM, 711 Tested
Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:147 Active, 45 Activity ≤ 1 µM, 1167 Tested
Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:70 Active, 31 Activity ≤ 1 µM, 1177 Tested
Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:10 Active, 1178 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:26 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 1184 Tested
Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:80 Active, 18 Activity ≤ 1 µM, 1172 Tested
Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
Assay data:29 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 845 Tested
Compound was evaluated for inhibition of human ABCB11 in an in vitro assay with cellular components measured by filtration, liquid scintillation counting
Assay data:43 Active, 3 Activity ≤ 1 µM, 508 Tested
Partial agonist activity at PPARgamma (unknown origin) by TR-FRET-based competitive binding assay
Assay data:1 Active, 1 Tested
Induction of adiponectin secretion in human BMMSC cells in presence of IDX induction medium by ELISA assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antimalarial activity against Plasmodium
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
Agonist activity at human PPARgammaDEF receptor expressed in african green monkey COS7 cells transfected with pGal5-TK-pGL3/pRenilla-CMV assessed as intrinsic activity measured after 39 hrs by dual luciferase reporter assay
Assay data:4 Active, 14 Tested
Inhibition of STAT5 phosphorylation in imatinib-resistant human K562 cells in presence of imatinib at 10 uM measured after 6 hrs by Western blot assay
Assay data:5 Active, 7 Tested
Modulation of TxA2 receptor in human platelet suspension assessed as lowest concentration that reduced U46619-induced platelet aggregation preincubated for 5 min followed by U46619 stimulation by light transmission aggregometry
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
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