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Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Inhibition of N-terminal GST-tagged human EGFR (696 to end aminoacids) expressed in baculovirus infected Sf21 cells
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate incubated for 90 mins by microfluidic off-Chip Mobility Shift Assay
Assay data:29 Active, 4 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 31 Tested
Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay
Assay data:158 Active, 1363 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
qHTS Assay for Inhibitors of N-terminal methyltransferase 1 (NTMT1): LOPAC validation of the NTMT1 SAHH-coupled ThioGlo3 Assay
Assay data:252 Active, 1280 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen
Assay data:1430 Active, 11 Activity ≤ 1 nM, 385 Activity ≤ 1 µM, 10968 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen
Assay data:1153 Active, 10968 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Human LCK proto-oncogene, Src family tyrosine kinase (Src family)
Assay data:22 Active, 22 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS Assay for inhibitors of the human cytomegalovirus (HCMV)
Assay data:18444 Active, 406408 Tested
SummaryCompounds, Active
qHTS assay to identify small molecule antagonists of the estrogen related receptor (ERR) signaling pathway
Assay data:134 Active, 29 Activity ≤ 1 µM, 1366 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Self-aggregating activity of the compound in phosphate buffer at pH 7.4 at 5 to 80 uM by 1D 1H-NMR spectroscopic analysis in absence of Tween 20
Assay data:2 Active, 14 Tested
The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. Cell Systems Volume 1, Issue 6, p383-395
Assay data:2021 Active, 5518 Tested
SummaryCompounds, ActiveRelated BioAssays by Same Project
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:1487 Active, 257 Activity ≤ 1 µM, 1607 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity_Set2
Assay data:41 Active, 113 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity_Set2
Assay data:109 Active, 8 Activity ≤ 1 µM, 113 Tested
qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT
Assay data:64212 Active, 1 Activity ≤ 1 nM, 3794 Activity ≤ 1 µM, 424003 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line
Assay data:7452 Active, 1 Activity ≤ 1 nM, 782 Activity ≤ 1 µM, 364851 Tested
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