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Inhibition of IL6-stimulated STAT3 signalling in human CD4+ T cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TYK2 (unknown origin)
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of JAK1 (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK3 (unknown origin)
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of JAK2 (unknown origin)
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Selectivity interaction (Enzyme kinetic assay (ProQinase)) EUB0000006b TYK2
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Enzyme kinetic assay (ProQinase)) EUB0000006b JAK2
Selectivity interaction (Enzyme kinetic assay (ProQinase)) EUB0000006b JAK1@kinase 1
Affinity Biochemical interaction (Radiometric inhibition assay) EUB0000006b JAK3
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000006b JAK3
Affinity Phenotypic Cellular interaction (pSTAT5 inhibition in CD4+ T cells) EUB0000006b JAK3
Kinase HotSpot Assay from Article 10.1016/j.chembiol.2016.10.008: "Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket."
Assay data:4 Active, 3 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Proteros Reporter Displacement Assay from Article 10.1016/j.chembiol.2016.10.008: "Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket."
JAK3 ELISA-based Kinase Activity Assay from Article 10.1016/j.chembiol.2016.10.008: "Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket."
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability in presence of 0.1 mM H2O2 by MTT assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability by MTT assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
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