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Inhibition of JAK3 (unknown origin)
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin)
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of STK25 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY7_PLB cell viability assay
Assay data:828 Active, 37 Activity ≤ 1 nM, 590 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS34_JCRB cell viability assay
Assay data:581 Active, 20 Activity ≤ 1 nM, 384 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay
Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS12PE_JCRB cell viability assay
Assay data:722 Active, 26 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: INA6_PLB cell viability assay
Assay data:965 Active, 40 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: AMO1_DSMZ cell viability assay
Assay data:746 Active, 20 Activity ≤ 1 nM, 455 Activity ≤ 1 µM, 1912 Tested
Inhibition of JAK 3 (unknown origin)
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of JAK 2 (unknown origin)
Assay data:15 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Antiproliferative activity against mouse BaF3 cells harbouring ABL-T315I mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against mouse BaF3 cells harbouring wild type ABL assessed as cell growth inhibition measured after 72 hrs by MTT assay
Inhibition of Abl T315I mutant (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
MELK Inhibitor Library Screening assay from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:13 Active, 3 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of DYRK2 (unknown origin) by NanoBRET cellular target engagement assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by CCK8 assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 12 Tested
Antiproliferative activity against human K562 cells assessed as reduction in cell growth measured after 72 hrs by CCK8 assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 12 Tested
Inhibition of Aurora B (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assay
Assay data:3 Active, 4 Activity ≤ 1 µM, 12 Tested
Inhibition of Aurora A (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assay
Assay data:9 Active, 5 Activity ≤ 1 µM, 12 Tested
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