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HepG2 viability counterscreen (readout 1: protease activity) against the NCATS DSHEA and TCM libraries
Assay data:10 Active, 1 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Total Cmax in human administered as single dose
Assay data:62 Active, 3 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 72 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
BK Channel Variant Modulator Selectivity Assay
Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway
Assay data:29 Active, 6 Activity ≤ 1 nM, 218 Activity ≤ 1 µM, 9315 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway
Assay data:93 Active, 7 Activity ≤ 1 nM, 178 Activity ≤ 1 µM, 9305 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line
Assay data:820 Active, 22 Activity ≤ 1 nM, 358 Activity ≤ 1 µM, 10486 Tested
qHTS assay for small molecule disruptors of the mitochondrial membrane potential
Assay data:1817 Active, 1 Activity ≤ 1 nM, 393 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation
Assay data:22396 Active, 20 Activity ≤ 1 nM, 19843 Activity ≤ 1 µM, 324050 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Dissociation constant against folic acid receptor (FAR); Value ranges from 0.1-1 nM
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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