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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Antiviral activity against influenza A virus
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of aurora B kinase (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
MELK Inhibitor Library Screening assay from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:13 Active, 3 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from Article 10.1021/acschembio.5b00940: "Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands."
Assay data:38 Active, 25 Activity ≤ 1 µM, 47 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate preincubated for 60 mins followed by substrate addition by microfluidic assay
Assay data:31 Active, 3 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 32 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay
Assay data:41 Active, 8 Activity ≤ 1 nM, 357 Activity ≤ 1 µM, 11292 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as substrate measured after 30 mins in presence of [gamma32P]ATP by liquid scintillation counting method
Assay data:19 Active, 3 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of Xenopus laevis aurora B (60 to 361 residues)/INCENP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation
Assay data:347 Active, 1 Activity ≤ 1 nM, 215 Activity ≤ 1 µM, 650 Tested
qHTS Screen of the MIPE 4.0 Collection Against Ewings Sarcoma (TC32)
Assay data:824 Active, 9 Activity ≤ 1 nM, 330 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Screen of the MIPE 4.0 Collection Against Ewings Sarcoma (EW8)
Assay data:764 Active, 1 Activity ≤ 1 nM, 243 Activity ≤ 1 µM, 1910 Tested
qHTS Screen of the MIPE 4.0 Collection Against Ewings Sarcoma (TC71)
Assay data:917 Active, 1 Activity ≤ 1 nM, 270 Activity ≤ 1 µM, 1910 Tested
qHTS Screen of the MIPE 4.0 Collection Against Ewings Sarcoma (RDES)
Assay data:857 Active, 2 Activity ≤ 1 nM, 257 Activity ≤ 1 µM, 1910 Tested
Antiprotozoal activity against Trypanosoma brucei 427 assessed as growth inhibition after 48 hrs by PrestoBlue-based fluorescence assay
Assay data:17 Active, 8 Activity ≤ 1 µM, 18 Tested
Antiprotozoal activity against promastigote stage of Leishmania major assessed as growth inhibition after 44 hrs by AlamarBlue staining-based fluorescence assay
Assay data:13 Active, 7 Activity ≤ 1 µM, 19 Tested
Antiprotozoal activity against Plasmodium falciparum D6 assessed as growth inhibition after 72 hrs by SYBR Green dye-based fluorescence assay
Assay data:18 Active, 16 Activity ≤ 1 µM, 19 Tested
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Assay data:10 Active, 2 Activity ≤ 1 µM, 19 Tested
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