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Cmax in Sprague-Dawley rat at 50 mg/kg, ip administered as single dose measured for 24 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation incubated for 48 hrs by Western blot analysis
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/EML4-ALK in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation incubated for 16 hrs by Western blot analysis
Antiproliferative activity against ALK-positive human KARPAS-299 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested
Antiproliferative activity against ALK-positive human NCI-H3122 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against ALK positive human SR cells
Assay data:37 Active, 3 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
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