Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Cytotoxicity against human OCILY10 cells assessed as reduction in cell viability measured after 12 days by CellTiter-Glo assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytotoxicity against human HBL1 cells assessed as reduction in cell viability measured after 12 days by CellTiter-Glo assay
Protac activity at IRAK1/VHL E3 ligase in human OCILY10 assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at IRAK1/VHL E3 ligase in human HBL1 assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Protac activity at IRAK1/VHL E3 ligase in HEK293T cells assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of full length human N-terminal GST-fusion tagged IRAK4 expressed in baculovirus expression system using FAM-labelled peptide as substrate preincubated for 10 mins followed by substrate addition and further incubated for 1 hr in presence of ATP at Km concentration by caliper mobility shift assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of truncated human N-terminal GST-fusion tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using FAM-labelled peptide as substrate preincubated for 10 mins followed by substrate addition and further incubated for 1 hr in presence of ATP at Km concentration by caliper mobility shift assay
Protac activity at VHL/IRAK1 in HEK293T cells assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on