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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:49 Active, 5 Activity ≤ 1 µM, 1243 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant PDE3 expressed in Escherichia coli
Assay data:15 Active, 12 Activity ≤ 1 µM, 16 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY5_PLB cell viability assay
Assay data:980 Active, 10 Activity ≤ 1 nM, 428 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS34_JCRB cell viability assay
Assay data:581 Active, 20 Activity ≤ 1 nM, 384 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MMM1_PLB cell viability assay
Assay data:911 Active, 7 Activity ≤ 1 nM, 657 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay
Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS12BM_JCRB cell viability assay
Assay data:870 Active, 12 Activity ≤ 1 nM, 424 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: JJN3_DSMZ cell viability assay
Assay data:743 Active, 23 Activity ≤ 1 nM, 495 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: ARP1_JJKsccF8 cell viability assay
Assay data:662 Active, 11 Activity ≤ 1 nM, 344 Activity ≤ 1 µM, 1912 Tested
Inhibition of PDE3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
qHTS Screen of the MIPE 4.0 Collection Against Ewings Sarcoma (TC71)
Assay data:917 Active, 1 Activity ≤ 1 nM, 270 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary
Assay data:251 Active, 1 Activity ≤ 1 nM, 173 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Assay data:9 Active, 5 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS
Assay data:4037 Active, 2427 Activity ≤ 1 µM, 392548 Tested
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation
Assay data:22396 Active, 20 Activity ≤ 1 nM, 19843 Activity ≤ 1 µM, 324050 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
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