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Enzyme Assay from US Patent US8592432: "Compounds and compositions as protein kinase inhibitors"
Assay data:61 Active, 61 Activity ≤ 1 µM, 61 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growth
Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cmax in rat at 10 mg/kg, po
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cmax in mouse at 20 mg/kg, po
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of IGF-1R (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of HER1 (unknown origin)
Inhibition of CDK2 (unknown origin)
Inhibition of ALK (unknown origin)
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
Inhibition of Tel fused InsR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay
Assay data:18 Active, 5 Activity ≤ 1 µM, 18 Tested
Inhibition NMP-ALK (unknown origin)
Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 18 Tested
Inhibition EML4-ALK (unknown origin)
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