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NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of rat liver COMT using esculetin as substrate by fluorescence based spectrophotometry
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate and SAM measured after 15 mins by chromatographic analysis
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate and SAM measured after 5 mins by chromatographic analysis
Assay data:14 Active, 13 Activity ≤ 1 µM, 16 Tested
Inhibition of COMT (unknown origin) in presence of AdoMet and Esculetin by reaction kinetic model based assay relative to control
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition of human recombinant His-tagged soluble COMT expressed in Escherichia coli BL21 using aesculetin as substrate after 60 mins by microplate assay in presence of SAM
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
qHTS assay to identify small molecule inhibitors of chordoma cells - UCH-1
Assay data:89 Active, 14 Activity ≤ 1 nM, 175 Activity ≤ 1 µM, 2815 Tested
qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen2, ratio channel
Assay data:637 Active, 202 Activity ≤ 1 µM, 2566 Tested
qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 ratio channel
Assay data:502 Active, 187 Activity ≤ 1 µM, 2552 Tested
Inhibition of Catechol O-methyltransferase activity in rat brain
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
qHTS Assay for Modulators of Lamin A Splicing
Assay data:27 Active, 88 Activity ≤ 1 nM, 6227 Activity ≤ 1 µM, 198098 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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