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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Cytotoxicity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:10 Active, 11 Activity ≤ 1 µM, 11 Tested
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:8 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of BRD4 BD1 (unknown origin) by TR-FRET assay
Assay data:21 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 21 Tested
SummaryRelated BioAssays by Target
Inhibition of BRD4 (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of Alexa647 labelled MS417 binding to his tagged BRD4 BD2 (unknown origin) by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Alexa647 labelled MS417 binding to his tagged BRD4 BD1 (unknown origin) by TR-FRET assay
TR-FRET Assay from US Patent US10633379: "Bromodomain inhibitors"
Assay data:130 Active, 8 Activity ≤ 1 nM, 130 Activity ≤ 1 µM, 130 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Bromodomain Domain Binding Assay from US Patent US9296741: "Bromodomain inhibitors"
Assay data:347 Active, 28 Activity ≤ 1 nM, 339 Activity ≤ 1 µM, 348 Tested
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of BRD4 bromodomain1 (unknown origin) using peptide histone H4 (SGRGACKGGACKGLGAC-KGGAACKRHGSGSK-biotin) as substrate incubated for 15 mins followed by substrate addition measured after 1 hr by alphascreen assay
Assay data:15 Active, 15 Activity ≤ 1 µM, 16 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Antiproliferative activity against human MM1S cells assessed as reduction in cell viability measured after 72 hrs by Celltitre-glo luminescence assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antiproliferative activity against human RS4:11 cells assessed as reduction in cell viability measured after 72 hrs by Celltitre-glo luminescence assay
Antiproliferative activity against human Kasumi-1 cells assessed as reduction in cell viability measured after 72 hrs by Celltitre-glo luminescence assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by Celltitre-glo luminescence assay
Assay data:16 Active, 16 Activity ≤ 1 µM, 26 Tested
Inhibition of MSGRGK(Ac)-GGK(Ac)GLGK(Ac)GGAKRHR-biotin binding to EP300 (1040 to 1160 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by Alphascreen assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 30 Tested
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