BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 18047131.

Transactivation assays from US Patent US10752616: "Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists"

Source:: BindingDB

Protein Targets:: Retinoic acid receptor alpha; ...
Total:: 3

Assay data:46 Active, 2 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested

AID:: 1804713

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17991832.

Retinoid Competition Binding Assay from Article 10.1006/jmbi.2000.4032: "Structural basis for isotype selectivity of the human retinoic acid nuclear receptor."

Source:: BindingDB

Protein Targets:: Retinoic acid receptor alpha; ...
Total:: 3

Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1799183

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16860253.

Agonist activity at human RAR

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1686025

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 16028334.

Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay

Source:: ChEMBL

Protein Target:: Retinoic acid receptor gamma

Assay data:18 Active, 2 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested

AID:: 1602833

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15762325.

Agonist activity at RAR (unknown origin) by Alpha Screen assay

Source:: ChEMBL

Protein Targets:: Retinoic acid receptor alpha; ...
Total:: 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1576232

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13728426.

Transactivation of mouse Gal4-fused RARgamma-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assay

Source:: ChEMBL

Protein Target:: Retinoic acid receptor gamma

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1372842

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13728397.

Transactivation of mouse Gal4-fused RARbeta-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assay

Source:: ChEMBL

Protein Target:: Retinoic acid receptor beta

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1372839

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13451998.

Drug repurposing screens with cells derived from glioblastoma tumor samples

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:1237 Active, 3 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 3733 Tested

AID:: 1345199

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 12594069.

BK Channel Variant Modulator Selectivity Assay

Source:: Horrigan Lab, Baylor College of Medicine

Protein Targets:: Leucine-rich repeat-containing protein 26; ...
Total:: 5

Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested

AID:: 1259406

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 112138810.

Inhibition of ROR beta (unknown origin)-mediated transactivation

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-beta

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1121388

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 97761111.

Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Cell division protein ftsZ; ...
Total:: 2972

Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested

AID:: 977611

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 39214212.

Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Retinoic acid receptor gamma

Assay data:6 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested

AID:: 392142

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 28857313.

Induction of terminal differentiation in mouse F9 cells assessed by measuring secreted plasminogen activator activity after 3 days

Source:: ChEMBL

Assay data:4 Active, 3 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 288573

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 28857214.

Reversal of keratinization in vitamin A-deficient hamster trachea after 10 days by TOC assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 288572

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 25425715.

Dissociation constant for Retinoic acid receptor gamma

Source:: ChEMBL

Protein Target:: Retinoic acid receptor gamma

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested

AID:: 254257

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 22031316.

Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA

Source:: ChEMBL

Protein Target:: Retinoic acid receptor beta

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 220313

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 22031217.

Binding affinity towards cRARbeta2 receptor by displacing 0.82 nM 3[H]all-trans-RA

Source:: ChEMBL

Protein Target:: Retinoic acid receptor beta

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 220312

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 21076918.

Inhibitory dose against tracheal organ culture reversal of keratinization

Source:: ChEMBL

Assay data:7 Active, 8 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested

AID:: 210769

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19996419.

Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma

Source:: ChEMBL

Protein Target:: Retinoic acid receptor RXR-gamma

Assay data:3 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 199964

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19980520.

Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR beta

Source:: ChEMBL

Protein Target:: Retinoic acid receptor RXR-beta

Assay data:3 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 199805

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (2)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (68)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (68)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (68)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (66)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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Literature Extraction (66)
BioAssays extracted from the literature
Other (1)
BioAssays deposited by other experimentalists

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