Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of wild type N-terminal GST tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 end residues) (unknown origin) expressed in Sf21 cells incubated for 1 hr in presence of ATP
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ALK (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibitory Activity Against Anaplastic Lymphoma Kinase (ALK) from US Patent US10053458: "Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient"
Assay data:107 Active, 20 Activity ≤ 1 nM, 107 Activity ≤ 1 µM, 107 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ALK L1196M mutant (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader method
Inhibition of N-terminal GST tagged wild-type human ALK cytoplasmic domain (1058-1620 amino acids) expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured after 90 mins by fluorescence based assay
Assay data:41 Active, 5 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 42 Tested
Inhibition of ALK T1151-L1152 insT mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of ROS1 L2026M mutant (unknown origin)
Assay data:5 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of wild type ROS1 (unknown origin)
Assay data:5 Active, 3 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of ALK (unknown origin) after 60 mins
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on