BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19190801.

Inhibition of ALK Tyrosine Kinase Activity from US Patent US11517561: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919080

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131422.

Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913142

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131413.

Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ALK

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913141

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19128914.

Affinity On-target Cellular interaction (Sandwich ELISA (cell-based ROS1-fusion assay)) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912891

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18040975.

Assay for Inhibition of ALK Tyrosine Kinase Activity from US Patent US10543199: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1804097

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17952456.

Inhibition Assay from US Patent US10780082: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1795245

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 16801037.

Inhibition of SLC34A2-ROS1 (unknown origin) expressed in human HCC78 cells assessed as reduction in cell viability

Source:: ChEMBL

Protein Targets:: Proto-oncogene tyrosine-protein kinase ROS; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1680103

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16801028.

Inhibition of ROS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1680102

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16801019.

Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viability

Source:: ChEMBL

Protein Targets:: HLA class II histocompatibility antigen gamma chain; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1680101

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 168010010.

Inhibition of ALK L1196M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1680100

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 167395811.

Inhibition of ROS1 L2026M mutant (unknown origin) in presence of ATP by microfluidic mobility shift assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1673958

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 149450012.

Inhibition of ALK L1196M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1494500

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 141963413.

Inhibition of ALK (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1419634

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 141962614.

Inhibition of wild type EML4/ALK F1174L mutant (unknown origin) expressed in NIH/3T3 cells

Source:: ChEMBL

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1419626

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 141962315.

Inhibition of ROS1 L2026M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:5 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1419623

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 141962216.

Inhibition of wild type ROS1 (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:5 Active, 3 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1419622

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 115311017.

Inhibition of ROS1 (unknown origin) by off-chip mobility shift assay

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1153110

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 115310318.

Inhibition of human EML4-fused ALK F1174L mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1153103

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 115309419.

Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to ATP addition measured after 1 hr by microfluidic mobility shift assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:29 Active, 14 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested

AID:: 1153094

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 115309320.

Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to ATP addition measured after 1 hr by microfluidic mobility shift assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:26 Active, 19 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested

AID:: 1153093

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (21)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (21)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (21)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (20)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (18)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssays, activity concentration at/below 1 nM for PubChem Compo... (21)
BioAssays, activity concentration at/below 1 nM for PubChem Compound (Select 71731823)
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PubChem BioAssay
Taxonomy Links for Protein (Select 2320295318) (1)
Taxonomy
Campylobacter sp. CNRCH_2013_0855 1, whole genome shotgun sequence
Campylobacter sp. CNRCH_2013_0855 1, whole genome shotgun sequence
gi|2320295707|ref|NZ_JAKMTE01000000 gnl|WGS:NZ_JAKMTE01|1

Nucleotide
Bryaninops yongei voucher USNM:FISH:395607 mitochondrion, complete genome
Bryaninops yongei voucher USNM:FISH:395607 mitochondrion, complete genome
gi|2373975023|gb|OP035304.1|

Nucleotide
DDX3Y DEAD-box helicase 3 Y-linked [Homo sapiens]
DDX3Y DEAD-box helicase 3 Y-linked [Homo sapiens]
Gene ID:8653

Gene

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