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Inhibition of human PDE4 expressed in Sf9 cells by non-linear regression analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PDE4 expressed in Saccharomyces cerevisiae preincubated for 30 mins followed by cAMP substrate addition
Antiinflammatory activity in rat whole blood assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiinflammatory activity in human whole blood assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by fluorescence linked immunosorbant assay
Assay data:16 Active, 14 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysis
Assay data:46 Active, 44 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 47 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production
Assay data:8 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of human recombinant PDE4B by scintillation proximity assay
Assay data:25 Active, 8 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
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