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Antiviral activity against EBV infected in Mononuclear cell assessed as viral growth inhibition incubated for 25 hrs by microscopic analysis
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against EBV infected in P3HR1 cells assessed as decrease in viral replication
Assay data:6 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against EBV infected in P3HR1 cells assessed as decrease in Rta cells at 10 uM measured after 24 hrs by Western blot analysis relative to control
Assay data:9 Tested
Binding affinity to EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 assessed as dissociation constant by spectrofluorimetric analysis
Assay data:3 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of recombinant EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 transformed into Escherichia coli FHK12 cells assessed as disruption of oligomerization by measuring ToxR transcription activity assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
Potency index, ratio of IC50 of pentamidine to IC50 of compound for inhibition of recombinant EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 transformed into FHK12 cells by ToxR assay
Reactivation of latent EBV infected in human MUTU-I cells incubated for 48 hrs by steady-glo luciferase reporter assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 18 Tested
Antiviral activity against Epstein-Barr virus
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against EBV infected in human Raji cells assessed as reduction in viral genome copy numbers by qRT-PCR analysis
Assay data:1 Active, 2 Tested
Reactivation of latent EBV infected in human MUTU-I cells incubated for 48 hrs by steady-glo luciferase reporter assay relative to C60
Assay data:6 Tested
Reactivation of latent EBV in human SNU-719 cells xenografted NSG mouse assessed as increase in BZLF1 protein level in tumor mass at 30 mg/kg, ip qd for 4 days starting from 28 days post infection by immunoblot analysis
Assay data:3 Active, 3 Tested
Reactivation of latent EBV in human AGS cells xenografted NSG mouse assessed as increase in BZLF1 protein level in tumor mass at 25 mg/kg, ip qd for 3 days starting from 42 days post infection by immunoblot analysis
Assay data:2 Active, 2 Tested
Displacement of TO from EB virus g4-EBNA1 mRNA measured after 5 mins by FID assay
Assay data:18 Active, 15 Activity ≤ 1 µM, 21 Tested
Antiviral activity against EBV infected in human AKATA cells assessed as reduction in IgG-induced lytic virus replication measured at 48 hrs post-lytic induction by qRT-PCR analysis
Assay data:2 Active, 6 Tested
Inhibition of Epstein-Barr virus-induced human B95-8 cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Raji cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Daudi cell proliferation after 72 hrs by MTT assay
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 2 mutant assessed as dissociation constant by SPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 2 assessed as dissociation constant by SPR assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 1 mutant assessed as dissociation constant by SPR assay
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