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Bactericidal activity against Streptococcus gordonii DL1 assessed as reduction in bacterial growth at 100 uM after 24 hrs
Assay data:2 Tested
SummaryPubMed Citation
Inhibition of planktonic growth of Streptococcus gordonii at 40 uM by standard optical density assay relative to control
Assay data:10 Tested
Potency index, ratio of doxycycline MBC=>99 to compound MBC=>99 for Streptococcus gordonii DL1
Bactericidal activity against Streptococcus gordonii DL1 preincubated for 24 hrs under anaerobic condition followed by incubation in columbia petri plates for 24 hrs by broth microdilution method
Assay data:14 Tested
Antibacterial activity against Streptococcus gordonii DL1 preincubated for 24 hrs under anaerobic condition followed by incubation in columbia petri plates for 24 hrs by broth microdilution method
Antibacterial activity against Streptococcus gordonii DL1 incubated for 24 hrs under anaerobic condition by agar dilution method
Growth inhibition of Streptococcus gordonii at 200 uM after 24 hrs
Assay data:1 Tested
Antimicrobial activity against Streptococcus gordonii assessed as inhibition of bacterial biofilm formation at 50 uM after 10 mins
Assay data:5 Tested
Antimicrobial activity against erythromycin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring R483P mutation in ptsI infected in Wistar rat assessed as protection against bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hrs for 2 days measured within 3 days post last dose
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation infected in Wistar rat assessed as protection against bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hrs for 2 days measured within 3 days post last dose
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI infected in Wistar rat assessed as decrease in bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hrs for 2 days measured within 3 days post last dose
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii infected in Wistar rat assessed as decrease in bacterial infection at 300000 U/kg, sc administered 16 hrs after infection every 12 hrs for 2 days measured within 3 days post last dose
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI assessed as decrease in [14C]glucose uptake at 2 ug/ml after 60 mins by liquid scintillation counting
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii assessed as decrease in [14C]glucose uptake at 2 ug/ml after 60 mins by liquid scintillation counting
Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation in ptsI after 24 hrs by macrodilution assay
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii after 24 hrs by macrodilution method
Antimicrobial activity against erythromycin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring R483P mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution technique
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii harboring P438R mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution technique
Antimicrobial activity against penicillin- and streptomycin-resistant Streptococcus gordonii Tol1 harboring Tol1 mutation in ptsI assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution assay
Antimicrobial activity against wild type streptomycin-susceptible Streptococcus gordonii assessed as bacterial count at 2 ug/ml after 24 hrs by macrodilution method
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