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Selectivity index, ratio of EC50 for antiviral activity against HCV GT-1b Con1 in human Huh-5-2 cells carrying HCV subgenomic replicon assessed as drug resistance measured after 15weeks in presence of G418 by NGS analysis to EC50 for antiviral activity against HCV GT-1b Con1 in human Huh-5-2 cells carrying HCV subgenomic replicon assessed as drug resistance measured after 30 passages in presence of G418
Assay data:2 Tested
SummaryPubMed Citation
Inhibition of HCV genotype 1b NS5A infected in HuH-7-Luc/Neo-ET cells assessed as reduction in viral replication measured by Luciferase reporter gene assay
Assay data:13 Active, 13 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HCV 1b NS3/4A protease preincubated for 45 mins in presence of compound
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of HCV 1b NS3/4A protease
Inhibition of recombinant full length NS3/4A D168V mutant protease in Hepatitis C virus subtype 1b replicon infected in human HuH7 cells preincubated for 3 days followed by substrate addition and measured after 2 hrs by renilla luciferase reporter gene assay
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of recombinant full length NS3/4A protease in Hepatitis C virus subtype 1b replicon infected in human HuH7 cells preincubated for 3 days followed by substrate addition and measured after 2 hrs by renilla luciferase reporter gene assay
Assay data:18 Active, 13 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of Hepatitis C virus 1b con1 NS5A
Inhibition of Hepatitis C virus 1b NS5A
Inhibition of NS5A in Hepatitis C virus subtype 1b infected in human HuH7 cells assessed as reduction in viral replication by luciferase reporter gene assay
Assay data:11 Active, 11 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 16 Tested
Inhibition of NS5A Y93H mutant in Hepatitis C virus subtype 1b
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NS5A L31V mutant in Hepatitis C virus subtype 1b
Inhibition of NS5A D168Y mutant in Hepatitis C virus subtype 1b
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of NS5A in HCV genotype 1b infected in HuH7.5Lcu-Neo cells assessed as reduction in viral replication by luciferase reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of NS5A D320E/Y321N mutant in HCV genotype 1b infected in HuH7.5Lcu-Neo cells assessed as reduction in viral replication by luciferase reporter gene assay
Inhibition of NS5A L31V mutant in HCV genotype 1b infected in HuH7.5Lcu-Neo cells assessed as reduction in viral replication by luciferase reporter gene assay
Inhibition of NS3 R155Q/A156T mutant in HCV genotype 1b infected in HuH7.5Lcu-Neo cells assessed as reduction in viral replication by luciferase reporter gene assay
Inhibition of NS5B S282T mutant in HCV genotype 1b infected in HuH7.5Lcu-Neo cells assessed as reduction in viral replication by luciferase reporter gene assay
Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo assay
Assay data:25 Active, 25 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysis
Assay data:25 Active, 1 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Inhibition of NS5B polymerase in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Assay data:15 Active, 11 Activity ≤ 1 µM, 15 Tested
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