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Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate addition
Assay data:52 Active, 11 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of HCV GT-3a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate addition
Assay data:32 Active, 1 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
Inhibition of HCV 3a NS3/4A protease preincubated for 45 mins in presence of compound
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of HCV 3a NS3/4A protease
Inhibition of recombinant full length NS3/4A protease in Hepatitis C virus subtype 3a replicon infected in human HuH7 cells preincubated for 3 days followed by substrate addition and measured after 2 hrs by renilla luciferase reporter gene assay
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Inhibition of recombinant full length NS3/4A protease in Hepatitis C virus subtype 3a infected in human HuH7 cells using Ac-Asp-Glu-Asp (EDANS)-Glu-Glu-Abu-(COO) Ala-Ser-Lys (DABCYL)-NH2 as substrate by FRET assay
Assay data:17 Active, 3 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of Hepatitis C virus 3a NS5A
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of NS5A in Hepatitis C virus subtype 3a infected in human HuH7 cells assessed as reduction in viral replication by luciferase reporter gene assay
Assay data:30 Active, 30 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luciferase reporter gene assay
Assay data:24 Active, 18 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Non-nucleoside inhibition of NS5B polymerase in HCV genotype 3a by Taqman probe based RT-PCR analysis
Assay data:25 Active, 10 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Potency index, ratio of AV-4025 IC50 to test compound IC50 for inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luciferase reporter gene assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HCV GT3a NS5A assessed as suppression of replicon RNA level by real-time PCR analysis
Assay data:36 Active, 26 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 48 Tested
Inhibition of HCV genotype 3a replicon NS5A
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of HCV genotype 3a replicons NS5A infected in human Huh7 cells by luciferase reporter gene assay
Assay data:17 Active, 5 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 26 Tested
Inhibition of NS5A in HCV genotype 3a assessed as decrease in viral replication
Assay data:18 Active, 17 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 26 Tested
Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
Assay data:21 Active, 21 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Inhibition of NS5A in wild type HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NS5A Y93H mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NS5A A30K mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
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