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Inhibition of Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta-gami B (DE3) assessed as reduction in consumption of NADPH using DHFA as substrate
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Pneumocystis carinii DHFR
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antipneumocystis activity against Pneumocystis carinii after 24 to 72 hrs by ATP-based luciferin-luciferase assay
Assay data:21 Active, 19 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antipneumocystis activity against Pneumocystis carinii at 100 ug/ml after 24 to 72 hrs by ATP-based luciferin-luciferase assay
Assay data:20 Active, 21 Tested
Inhibition of Pneumocystis carinii DHFR K37Q/F69N mutant by spectrophotometric assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Pneumocystis carinii DHFR K37Q mutant by spectrophotometric assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Pneumocystis carinii DHFR by spectrophotometric assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antimicrobial activity against Pneumocystis carinii assessed as ATP level detection by bioluminescence assay
Assay data:14 Active, 5 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of Pneumocystis carinii thymidylate synthase using MTHF and dUMP as substrates
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Ratio of pentamidine IC50 to compound IC50 for Pneumocystis carinii assessed as ATP level detection by bioluminescence assay
Summary
Inhibition of Pneumocystis carinii thymidylate synthase using MTHF and dUMP as substrates at 100 uM
Assay data:4 Tested
Assay data:26 Active, 14 Activity ≤ 1 µM, 28 Tested
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested
Ratio of trimethoprim IC50 to compound IC50 for Pneumocystis carinii DHFR
Assay data:1 Tested
Ratio of piritrexim IC50 to compound IC50 for Pneumocystis carinii DHFR
Antipneumocystis activity against Pneumocystis carinii assessed as reduction of ATP level after 72 hrs by bioluminescent assay
Assay data:17 Active, 19 Tested
Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as reduction of number of apoptotic alveolar macrophages at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days
SummaryPubMed Citation
Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as reduction of organism burden in lungs at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days
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