PubChem BioAssay Links for Taxonomy (Select 562) - PubChem BioAssay - NCBI

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Select item 19575121.

Antibacterial activity against Escherichia coli

Source:: ChEMBL

Assay data:4 Active, 4 Tested

AID:: 1957512

Summary Compounds, Active PubMed Citation

Select item 19563952.

Inhibition of Escherichia coli OGDHc E1 subunit assessed as inhibition constant preincubated for 60 mins followed by alpha-ketoglutarate addition using 30 uM ThDP as substrate by microplate reader analysis

Source:: ChEMBL

Assay data:2 Active, 2 Tested

AID:: 1956395

Summary Compounds, Active PubMed Citation

Select item 19563913.

Inhibition of Escherichia coli OGDHc E1 subunit assessed as DCPIP reduction preincubated for 60 mins followed by alpha-ketoglutarate addition using 30 uM ThDP as substrate by microplate reader analysis

Source:: ChEMBL

Assay data:2 Tested

AID:: 1956391

Summary PubMed Citation

Select item 19558694.

Inhibition of Escherichia coli ErmC methyltransferase

Source:: ChEMBL

Protein Target:: 23S rRNA methylase leader peptide

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1955869

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19557685.

Antibacterial activity against wild type Escherichia coli harbouring TolC-deficient mutant with pore

Source:: ChEMBL

Assay data:5 Active, 4 Activity ≤ 1 µM, 9 Tested

AID:: 1955768

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19557676.

Antibacterial activity against wild type Escherichia coli harbouring TolC-deficient mutant

Source:: ChEMBL

Assay data:5 Active, 2 Activity ≤ 1 µM, 9 Tested

AID:: 1955767

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19557667.

Antibacterial activity against wild type Escherichia coli harbouring pore

Source:: ChEMBL

Assay data:1 Active, 9 Tested

AID:: 1955766

Summary Compounds, Active PubMed Citation

Select item 19557658.

Antibacterial activity against Escherichia coli

Source:: ChEMBL

Assay data:8 Tested

AID:: 1955765

Summary PubMed Citation

Select item 19557509.

Antibacterial activity against Escherichia coli BW25113

Source:: ChEMBL

Assay data:1 Tested

AID:: 1955750

Summary PubMed Citation

Select item 195504210.

Inhibition of Escherichia coli DNA gyrase ATPase activity using pBR322 as substrate incubated for 10 mins in presence of NADH and ATP by supercoiling assay

Source:: ChEMBL

Protein Targets:: DNA gyrase subunit A; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1955042

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195501511.

Inhibition of ribosome dependent GTPase activity of Escherichia coli LepA

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1955015

Summary Compounds, Active PubMed Citation

Select item 195501412.

Inhibition of ribosome dependent GTPase activity of His-tagged Escherichia coli IF2

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1955014

Summary Compounds, Active PubMed Citation

Select item 195441513.

Binding affinity to Escherichia coli FMN riboswitch RNA assessed as dissociation constant

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1954415

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 195397814.

Binding affinity to Escherichia coli K12 glutaminyl-tRNA synthetase assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Glutamine--tRNA ligase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953978

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 195397715.

Binding affinity to Escherichia coli K12 Prolyl-tRNA synthetase

Source:: ChEMBL

Protein Target:: Proline--tRNA ligase

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1953977

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 195397416.

Binding affinity to Escherichia coli methionyl adenylate synthetase

Source:: ChEMBL

Assay data:1 Tested

AID:: 1953974

Summary PubMed Citation

Select item 195397117.

Inhibition of Escherichia coli K12 methionyl tRNA synthetase

Source:: ChEMBL

Protein Target:: Methionine--tRNA ligase

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1953971

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195395118.

Inhibition of Escherichia coli RNA polymerase

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953951

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 195394519.

Inhibition of MraY in Escherichia coli

Source:: ChEMBL

Assay data:11 Active, 2 Activity ≤ 1 µM, 15 Tested

AID:: 1953945

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 195394420.

Inhibition of MraY in Escherichia coli K12

Source:: ChEMBL

Protein Target:: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Assay data:8 Active, 5 Activity ≤ 1 µM, 8 Tested

AID:: 1953944

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (200)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (4,176)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (103)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (1,383)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (3)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (3,543)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (6)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (28)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (22,599)
BioAssays extracted from the literature
NIH MLP (33)
BioAssays deposited by the NIH Molecular Libraries Program
Other (26)
BioAssays deposited by other experimentalists

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PubChem BioAssay Links for Taxonomy (Select 562) (22659)
PubChem BioAssay
MAG: uncultured Nocardioides sp. isolate SRR3962771_bin.13_MetaWRAP_v1.3_MAG, wh...
MAG: uncultured Nocardioides sp. isolate SRR3962771_bin.13_MetaWRAP_v1.3_MAG, whole genome shotgun sequencing project
gi|2498553259|emb|CATMNG000000000.1 NG010000000

Nucleotide
Homo sapiens adaptor related protein complex 1 subunit beta 1 (AP1B1), transcrip...
Homo sapiens adaptor related protein complex 1 subunit beta 1 (AP1B1), transcript variant 2, mRNA
gi|1890346350|ref|NM_145730.3|

Nucleotide
PREDICTED: Homo sapiens HECT and RLD domain containing E3 ubiquitin protein liga...
PREDICTED: Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), transcript variant X40, mRNA
gi|2462546478|ref|XM_054379095.1|

Nucleotide
PREDICTED: Homo sapiens HECT and RLD domain containing E3 ubiquitin protein liga...
PREDICTED: Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), transcript variant X21, mRNA
gi|2462546438|ref|XM_054379075.1|

Nucleotide

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