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Inhibition of recombinant Fasciola hepatica CL3 expressed in Pichia pastoris at 20 uM using Z-Gly-Pro-Arg-NHMec as fluorogenic substrate preincubated for 15 mins followed by substrate addition by spectrophotometry analysis
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of recombinant Fasciola hepatica CL1 expressed in Pichia pastoris at 20 uM using Z-Leu-Arg-NHMec as fluorogenic substrate preincubated for 15 mins followed by substrate addition by spectrophotometry analysis
Antifasciola activity against adult stage of Fasciola hepatica Italian assessed as effect on parasite motility after 72 hrs
Assay data:2 Tested
Antifasciola activity against immature stage of Fasciola hepatica Italian assessed as effect on parasite motility after 72 hrs
Antifasciola activity against newly excysted juveline stage of Fasciola hepatica Italian assessed as effect on parasite motility after 72 hrs
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Antifasciola activity against newly excysted juveline stage of Fasciola hepatica Italian assessed as effect on parasite phenotype after 72 hrs
Antifasciola activity against immature stage of Fasciola hepatica Italian assessed as exposure of basal lamina at 13.3 uM after 72 hrs by osmium tetroxide staining-based scanning electron microscopic method
Assay data:1 Active, 1 Tested
Antifasciola activity against immature stage of Fasciola hepatica Italian assessed as sloughing of tegument at 13.3 uM after 72 hrs by osmium tetroxide staining-based scanning electron microscopic method
Antifasciola activity against immature stage of Fasciola hepatica Italian assessed as loss of spines on ventral surface at 13.3 uM after 72 hrs by osmium tetroxide staining-based scanning electron microscopic method
Antifasciola activity against adult stage of Fasciola hepatica Italian assessed as decoration of ventral surface by swollen tegumantal ridges and smaller spines at 40 uM after 72 hrs by osmium tetroxide staining-based scanning electron microscopic method
Antiparasitic activity against 10 week old Fasciola hepatica infected in sheep assessed as reduction in worm burden at 15 mg/kg, po
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as fluke reduction at 4 mg/kg, sc
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as fluke reduction at 4 mg/kg, intramuscular
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as fluke reduction at 12 mg/kg, po
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as reduction of eggs at 4 mg/kg, sc
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as reduction of eggs at 4 mg/kg, intramuscular
Antiparasitic activity against Fasciola hepatica infected in sheep assessed as reduction of eggs at 12 mg/kg, po
Antiparasitic activity against Fasciola hepatica assessed as mortality at 10 mg/L after 72 hrs relative to untreated control
Antiparasitic activity against Fasciola hepatica assessed as mortality at 50 mg/L after 72 hrs relative to untreated control
Antiparasitic activity against Fasciola hepatica assessed as mortality at 10 mg/L after 48 hrs relative to untreated control
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