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Cmax in non-human primates at 1 mg/kg, po
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Prodrug conversion in primates lungs assessed as NTP formation by measuring half life
Assay data:1 Tested
SummaryPubMed Citation
Oral bioavailability in non-human primates at 1 mg/kg
AUC in non-human primates at 1 mg/kg, po
Half life in non-human primates at 1 mg/kg, po
AUC in non-human primates at 1 mg/kg, iv
Clearance in non-human primates at 1 mg/kg, iv
Volume of distribution at steady state in non-human primates at 1 mg/kg, iv
Half life in non-human primates at 1 mg/kg, iv
Cardiotoxicity in non-human primates assessed as development-limiting toxicity
Toxicity in non-human primates assessed as development-limiting toxicity
Unbound brain-to-plasma concentration ratio in non-human primates by positron emission tomography
Unbound brain-to-plasma concentration ratio in non-human primates administered orally and measured after 120 mins by LC/MS/MS analysis
Assay data:3 Tested
Cmax in nonhuman primate at 10 mg/kg, po
Toxicity against non-human primate hepatocytes infected with liver stage Plasmodium cynomolgi B incubated for 4 days starting on day 4 post-sporozoite inoculation
Assay data:4 Tested
Toxicity against non-human primate hepatocytes infected with liver stage Plasmodium cynomolgi B incubated for 4 days from sporozoite addition
Assay data:1 Active, 4 Tested
Decrease in LDL level in non-human primates at 5 mg/kg once daily for 2 weeks
Increase in HDL level in non-human primates at 5 mg/kg once daily for 2 weeks
Toxicity in non-human primates assessed as adverse postmortem effect up to 20 mg/kg, po treated for 3 months
Toxicity in non-human primates assessed as adverse antemortem effect up to 20 mg/kg, po treated for 3 months
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