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Antiplatelet aggregation activity in rhesus monkey platelet rich plasma assessed as reduction in collagen-induced platelet aggregation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiplatelet aggregation activity in rhesus monkey platelet rich plasma assessed as reduction in ADP-induced platelet aggregation
Inhibition of monkey 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysis
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to monkey albumin
Inhibition of monkey aorta homogenate ACAT
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of monkey liver microsomes ACAT
Inhibition of monkey intestinal microsomes ACAT
Antiglaucoma activity in ocular hypersensitive monkey assessed as reduction in intraocular pressure
Cmax in monkey at 10 mg/kg,po by LC/MS/MS analysis
Assay data:3 Tested
SummaryPubMed Citation
Antimalarial activity against Plasmodium cynomolgi infected in rhesus macaque hepatocytes assessed as inhibition of liver-stage schizonts by Giemsa staining based microscopic analysis
Assay data:1 Tested
Antagonist activity at monkey TLR7 expressed in Drosophila S2 cells by ITC analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of rhesus monkey Nav1.7 at voltage yielding 20% channel inactivation by manual patch-clamp assay
Inhibition of monkey NNMT preincubated for 30 mins followed by substrate, cofactor addition and measured after 60 mins using nicotinamide as substrate and SAM as cofactor by fluorescence enzymatic assay
Drug metabolism in monkey intestinal microsomes assessed as rate of metabolism
Stability in monkey liver microsomes assessed as half life
Assay data:2 Tested
Inhibition of rhesus monkey blood platelet aggregation at 1 mg/kg, po
Inhibition of Rhesus monkey blood platelet aggregation at 4 mg/kg, po
Drug uptake in iv dosed monkey brain assessed as standardized uptake value after 90 mins by PET imaging analysis
Stability in monkey plasma assessed as compound remaining at 40 uM incubated for 6 hrs
Stability in monkey plasma assessed as compound remaining at 1 uM incubated for 6 hrs
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