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Inhibition of pig brain tubulin polymerization by spectrophotometeric analysis
Assay data:5 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Metabolic stability in minipig hepatocytes assessed as intrinsic clearance measured per 10^6 cells
Assay data:1 Tested
SummaryPubMed Citation
Metabolic stability in minipig liver microsomes assessed as intrinsic clearance
Metabolic stability in mini-pig liver microsomes assessed as compound remaining after 1 hr
Cmax in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Assay data:3 Tested
Cmax in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of pig brain tubulin polymerization at 12.5 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization at 3 uM by spectrophotometer analysis relative to control
Apparent oral clearance in Gottingen minipig at 20 mg/kg measured upto 24 hrs by HPLC-MS method
AUC (0 to t) in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Clearance in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
AUC (0 to t) in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Protein binding in minipig plasma assessed as unbound fraction
Stability in minipig hepatocytes assessed as parent compound remaining incubated for 60 mins
Inhibition of pig brain GSK alpha/beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate in presence of [gamma-33P]ATP by radiometric assay
Assay data:2 Active, 8 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of pig brain GSK alpha/beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate in presence of ATP measured after 30 mins by ADP-Glo assay
Assay data:6 Tested
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